Abstract: An attempt was made to design and develop mucoadhesive tablet formulation of Voriconazole against candida albicans in immunocompromised pateints. Poorly soluble drugs are very challenging to formlate in oral mucoadhesive dosage form. Whereas lipophilic drugs, well absorbed through oral mucosa, but shows very low fluxes hence exhibit difficulty in transport across mucosa. The complexation of Voriconazole with β- cyclodextrin was studied by phase solubility method which indicates the formation of complex with 1:1 stoichiometry. The muccoadhesive tablets for the delivery of Voriconazole were prepared by compression using carbopol and HPMC. The assessment of buccal administration of Voriconazole was analyzed by penetration through in-vitro excised goat mucosa. The results of experimented study reveals that, as there was increase in drug release rate from the tablets in solution as well as an increase in the amount of Voriconazole permeated through sheep buccal mucosa. An attempt was made to study the suitability of posacanazole in buccal drug delivery system.