Abstract- In this chapter the use of a full-thickness murine model was implemented to test the efficacy of ACP combined and activated on demand with electrospun type I bovine collagen scaffolds. A total of four, Severe Combined Immunodeficiency (SCID) 8-week female mice were purchased from Jackson Labs (albino, without hair genotype: A/A Tyr^c/Tyr^c Foxn1^nu/Foxn1^n)u) and used in this experiment. The mice had 5 full-thickness dorsal dermal punches created in a sterile operating room using sterile techniques. The wounds were assessed at pre-determined time intervals until euthanization occurred, at which time tissue collection was implemented for histological analysis. Histological assessment showed increased epithelial thickness and the presence of intradermal adipocytes indicative of a specific phase in the normal wound healing cycle. Based on both gross wound percent closure and histological assessment the use of ACP and collagen scaffolds reduces wound healing time, can positively impact the reforming stratum corneum, thus can be stated offers a favorable treatment modality for full-thickness wound closure.