Heterocyclic compounds consist of the precise and indispensable key compounds in organic chemistry. The fundamental significance is due to their various pharmaceutical properties resulting in many researchers being involved in the synthesis of these compounds. Many heterocyclic compounds containing pyrrole, pyrazole, oxazole, pyrimidine moiety, and Schiff’s bases approach the predictable antibacterial and antifungal activities. The quest for a more reliable and suitable drug is always fascinating and challenging. Several drugs containing simple heterocyclic or a combination of different heterocyclic moieties have been used these days. Cyclic imides such as succinimide exist the segment of many active molecules holding activities for instance analgesic, CNS-depressant, anti-tumor, cytostatic, hypotensive, anorectic, nerve-conduction-blocking, anti-spasmodic, bacteriostatic, muscle relaxant, antibacterial, antifungal and anti-convulsant. Glutarimide moiety with the complete imide group substituted at α, β position in the ring transfers the trace molecule and conveys the bio-active substituents over the cell membranes. Formylation is a fundamental route of organic synthesis subsequently the formation of aldehyde which plays an intermediate role. The Formyl chalcones are very important intermediates and building blocks widely employed in the synthesis of diverse pyrazole and pyrimidine systems. Bis-chalcones are the synthetic and naturally occurring flavonoids present in a variety of foodstuffs. These are recently focused on pharmacological, medicinal, and several synergistic groups of biological activities. Chalcone-based pyrimidines show a wide range of applications in medicines. All the compounds in the research scheme were synthesized by conventional and microwave synthetic methods. All these synthesized cyclic imides may be used for the preparation of various heterocyclic systems such as chalcones, and pyrimidines. The development of bis-chalcone involves the treatment of cyclic imides and vanillin in neutral alumina. Correspondingly the synthesis of the substituted amino-pyrimidines was also prepared by bis-chalcones and guanidine nitrate with neutral alumina. All the synthesized compounds were found reasonable antibacterial activities counter to Bacillus subtilis gram +ve and Escherichia coli gram -ve bacterial strains. Likewise, they showed significant to good activities against fungal strains Candida albicans and Aspergillus niger. Out of these, some of the compounds exhibited synergistic antifungal activities.