Abstract- Healthcare costs continue to rise as do a variety of diseases and disorders that correlate with full-thickness wounds. As a result, finding treatment solutions that areboth effective and cost efficient are important. It is evident in both the current literature and the findings in this dissertation, that platelet-rich plasma has pre-clinical and clinical efficacy. In this paper, the research findings are reviewed, demonstrating that platelet-rich plasma and collagen scaffolds decrease wound healing time. As a result, an amendment to the current clinical PRP definition is suggested due to positive findings that the “on-demand” activation of PRP has in a full-thickness wound. Additionally, the findings of this project will be discussed and how these findings could lead to additional work that may impact PRP treatment modalities in the clinicalfield.