PHARMACOLOGICAL EVALUATION OF SWIETENIA MACROPHYLLA SEED EXTRACT AS ANALGESIC AND ANTI-INFLAMMATORY PREOPERTIES IN MICE

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Shivram Krishna

Background and objective: Several studies in analgesic and anti-inflammatory activity identifying the natural treating agents with better safety profile against synthetic drug. The current study was observed the analgesic and anti-inflammatory activities through methanolic seed extract of Swieteniamacrophylla. The present study was designed as pharmacological evaluation of Swieteniamacrophylla seed extract as analgesic and anti-inflammatory properties in mice.

Materials and Method: The pharmacological activity of Swieteniamacrophylla seed was performed at the dose of 100 mg/ kg, 200 mg/kg and Aspirin 100 mg/kg, diclofenac 10 mg/kg. The analgesic activity was resolute through; hot-plate method, tail-flick method, acetic-acid writhing response in mice, even as in anti-inflammatory activity was determined by; carrageenan-induced paw edema, xylene-induced ear edema assay, formaldehyde-induced inflammatory activity studies were performed.

Results and discussion: Methanolic seed extract of Swieteniamacrophylla showed significant analgesic and anti-inflammatory activity against disease control group. In chronic anti-inflammatory activity test and standard drug act on the cytokines mediators affect like; IL-6, IL-10 and TNF-α. Analgesic and anti-inflammatory activity of methanolic seeds extract of Swieteniamacrophylla King was determined by the comparison between test and standard drug on the basis of improvement in elevated levels of biomarkers such as; cytokines level of TNF-α, IL-6, IL-10, COX-1, COX-2 and opioid receptors. Then the methanolic seed extract of Swieteniamacrophylla (100 and 200 mg/kg) was more significance effective as compared to standard drug (Diclofenac 10 mg/kg and Aspirin 100 mg/kg) on the basis evaluation of all over biological parameter and histopathological activities.

Conclusion: Finally it was conclude that the methanolic seed extract of Swieteniamacrophylla showed excellent analgesic and anti-inflammatory activity but in chronic inflammatory activity showed 80 to 90% effect due to presence of alkaloids, tannins, phenol, terpenoids, flavonoids, carbohydrate and glycosides.

Swieteniamacrophylla,TNF-α,IL-6,IL-10,COX-1andCOX-2.