Abstract-Laboratory simulation as a method to teach evaluation of efficacy and safety of botanical oils for skin care applications can stimulate students to develop scientific reasoning and increase their knowledge by providing additional resources and materials that relate to differential bioactivity and potential overuse toxicity associated with their topical application to the skin. As a nonintoxicating, pharmacologically relevant constituent of hemp oil, cannabidiol (CBD) exerts a number of skin health promoting effects, including anti-inflammatory and neuroprotective activity. While CBD-rich hemp is widely touted as a miracle panacea to manage skin ailments, hemp tissues used to produce hemp may become contaminated by THC-rich trichomes of hemp flowers and thus acquire THC. In this study, we investigated the use of role play and scenarios to educate students about the therapeutic potential of CBD-rich hemp and promote active learning, critical understanding, teamwork, and leadership towards addressing the putative side effects associated with its use. The scenarios reproduced skin care situations in the beauty salon industry which allowed us to evaluate and discuss exposure to Cannabis-derived CBD and THC. Four additional fact sheets focused on dermatological, toxicological, neurological and psychiatric aspects of Cannabis use assisted with reflections and debriefing of the students. The strategy presented here can facilitate the teaching-learning process of students, and can be easily transferred and applied in other educational institutions for the safe and effective method to study application of botanical to skin care.