Formulation of Etodolac as micro sponge drug delivery system

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Dr.B.Ravindra babu, Dr.V.Swapna, Eshrath

ABSTRACT: Etodolac (ED) is a drug which belongs to NSAIDs and is classified as class II by Biopharmaceutical classification system (BCS) with low solubility and high permeability. The aim of present study was to formulate Etodolac (ED) as a micro sponge technology. This enhances the release of drug from the system. ED is a drug belongs to NSAID groups that classified as class II by

BCS with low solubility and high permeability. This technology is a patented delivery system in which the drug loaded in pores of cross-linked polymers. In this technique, ED was mixed with two phases. In phase I and phase II, the polyvinyl alcohol (PVA) and Eudragit E100 were used, respectively, with a different doses of ED. The micro sponge yield, entrapment efficacy, FTIR, particle size, and dissolution test were all studied. Preparation of ED loaded micro sponge using Eudagit E100 in ratio of (500 Drug: 100 Polymer) succeed to enhance the drug dissolution rate with accepted entrapment efficiency and percentage yield.

Micro sponges, Etodolac, solubility.