This study aimed to investigate the in vitro skin permeation of curcumin by using liposomes as the transdermal drug-delivery system. Soybean phospholipids (SPC) and cholesterol were selected for the preparation of different kinds of phospholipids composed of curcumin-loaded liposomes. Liposomes have been loaded by Turmeric extract as a model drug using thin film hydration technique for targeted delivery of this drug. Turmeric extract containing liposomes with an encapsulation efficiency of 89.67 % were prepared, and the in vitro release of Turmeric extract from the liposomes. In conclusion, the formulation was optimized, the prepared liposomes had a high Turmeric extract encapsulation rate and good reproducibility, and there in vitro release had a certain delayed-release effect.