FORMULATION AND EVALUATION OF NADOLOL FLOATING TABLETS

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B. SWATHI, P.MANICHANDRIKA, GARIKAPATI KEERTHI, KOGURU MANIDEEPIKA, GOLLA ANUSHA, KARRA AMULYA REDDY, LINGALA HARIKA REDDY

The oral route of administration gets the highest priority for the delivery of drugs as well as better patient compliance.  The floating tablet is selected for achieving a prolonged and predictable drug delivery profile in the gastrointestinal tract to control the gastric residence time using gastro retentive dosage forms that will provide us with new and important therapeutic options.   The design of oral controlled drug delivery systems is aimed primarily to achieve more predictable and increased bioavailability.However, thesesystems have several physiological difficulties, such as the inability to restrain and localized oral control drug delivery systems within desired reasons of the gastrointestinal tract and the highly variable nature of the gastric emptying process. Gastric emptying time in humans, which is normally 2-3 hours through the main absorption area (stomach or upper part of intestine),can result in incomplete drug release from an oral controlled drug delivery system leading to diminished efficacy of an administered dose. Intimate contact of the oral controlled drug delivery system with the absorbing membrane has the potential to maximize drug absorption and also influence the rate of drug absorption.These considerations have lead to the development of oral controlled gastroretentive dosage forms possessing gastric retention capabilities. Nadolol floating tablets are used to treat and prevent ulcers in the stomach and intestines. Hence in the present study, an attempt will be made to develop floating tablets of Nadolol to sustain its release in the stomach and the upper part of the GIT.

Gastro retentive drug delivery system, Nadolol, Polymers, sodium bi carbonate and citric acid, in vitro drug release studies.