ABSTRACT : Gel formulations are becoming pre-eminent among the various semi-solid dosage forms utilized for topical treatment. These preparations are known as semi-solids because the medication is dissolved in the liquid media. Gels consist of natural or manufactured polymers joined by ionic, chemical or physical interactions to form three-dimensional structure. A family of medications known as antiviral drugs is specifically intended to treat viral infections. Antiviral medications are those that fight viral infections. The aim of the study was to create a topical antiviral gel. Compared to oral and intravenous delivery, topical application of drugs offers numerous benefits. In addition to avoiding the risk of gastrointestinal disorders and the discomfort of intravenous therapy, it stops the liver from metabolizing drugs. Applying the medication topically allows it to enter the skin more deeply, improving the absorption and bioavailability. Antiviral medications that specifically target viruses include those that block virus attachment, entrance, uncoating, polymerase, protease, nucleoside and nucleotide reverse transcriptase, and integrase inhibitors. The gel’s maximal medication content was achieved by employing 1%- Carbopol. The compositions viscosity ranged from 36,000-51,000 cps, while their pH ranged from 6.8-7.2. The Carbopol and CMC gels were more extrudable than the sodium CMC gel. According to the spreadability statistics, the formulation containing 1% Carbopol-934 has the highest value, whereas the other formulations have significant value.