Abstract: In the present work an attempt is being made to provide for stable drug delivery system with or having improved therapeutic index for Quercetin in form of lyophilized liposomes. Liposomes have been loaded by Quercetin as a model drug using thin film hydration technique for targeted delivery of this drug. Quercetin containing liposomes with an encapsulation efficiency of 90.05% were prepared, and the in vitro release of Quercetin from the liposomes complied with a first-order kinetic equation. In conclusion, the formulation was optimized, the prepared liposomes had a high Quercetin encapsulation rate and good reproducibility, and their in vitro release had a certain delayed-release effect.