Abstract: Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia associated with disturbances in carbohydrate, lipid, and protein metabolism. The present study was undertaken to evaluate the glucose lowering potential of Ficus carica in streptozotocin (STZ)-induced diabetic rats. The plant extract was subjected to preliminary phytochemical screening, which revealed the presence of flavonoids, phenolic compounds, tannins, alkaloids, glycosides, saponins, and terpenoids. Experimental diabetes was induced in Wistar rats by a single intraperitoneal injection of STZ (45–55 mg/kg). The animals were divided into five groups consisting of normal control, diabetic control, standard-treated (Metformin), and two extract-treated groups receiving Ficus carica extract at doses of 200 mg/kg and 400 mg/kg, respectively. The treatment was continued for 21 days, and various biochemical parameters including fasting blood sugar, oral glucose tolerance test, serum insulin, lipid profile parameters (TC, TG, LDL, HDL, VLDL), and antioxidant markers such as Superoxide Dismutase (SOD), Reduced Glutathione (GSH), and Glutathione-S-Transferase (GST) were evaluated. The results showed that Ficus carica extract significantly reduced elevated blood glucose levels and improved glucose tolerance in diabetic rats. The extract also improved serum insulin levels and restored altered lipid profile parameters toward normal values. Furthermore, treatment with Ficus carica significantly enhanced antioxidant enzyme levels, indicating its protective effect against oxidative stress induced by diabetes. The higher dose (400 mg/kg) exhibited more pronounced pharmacological activity comparable to the standard drug Metformin. Ficus carica possesses significant antihyperglycemic, antihyperlipidemic, and antioxidant activities and may serve as a potential natural therapeutic agent for the management of diabetes mellitus and its associated complications.