ABSTRACT: The most constant contamination to impact women is chest infection. An assigned medication transport framework for an anticancer expert is supposed to treat chest threatening development (BC) cells to the fitting supportive potential without endangering sound cells. The primary target of this work is to upgrade and consolidate silver nanoparticles (AgNPs) for oral usage in a viable and normally very much arranged way. Additionally, using animal models and harmful development cell lines, AgNPs stacked ME will be investigated for antibacterial and anticancer properties. Palbociclib is a fabricated solution having strong anticancer effects against chest illness. A cerebrum association (NN) smoothing out methodology was used to consolidate AgNPs and conclude the association between the arrangement parts and response factors (AgNPs size). For the predominant AgNPs in the AgNPs stacked ME specifying, evaluations were driven with respect to particle size and shape, morphological characterization, atom charge, and in vitro drug release assessments. The 3-factor, D-ideal mix model and the pseudo-ternary stage frame were used for the mix and evaluation of AgNPs stacked ME. The microemulsion containing silver nanoparticles was evaluated for its physicochemical properties, particle size, shape, surface morphology, zeta potential and in vitro release measures. AgNPs stacked ME show dynamic prescription release, which extends the drug’s useful concentration and bioavailability in dangerous development cells appeared differently in relation to sound cells. As well as having unprecedented anticancer potential against MCF-7 sickness cells, the made AgNPs in the AgNPs-stacked micro emulsion may similarly have the choice to stop the advancement of microorganisms. The in-vivo focus on uncovered that, conversely, with the development control, swallowing AgNPs-stacked ME definitions conclusively reduced the disease mass and Ehrlich ascites solid development improvement rate in the mice. The results show that AgNPs in AgNPs stacked ME appear to be encouraging as an anticancer therapy concerning strength, cost, and straightforwardness of production.