Abstract: Carbamazepine is a tricyclic Compound that is most efficient against partial seizures with it without secondary generalization. The introduction of carbamazepine into the area of epilepsy specified a new phase to control epileptic attacks. The variability in response to carbamazepine may be due to differences in pharmacokinetics, pharmacodynamics of drugs and ethnicity of individuals. ADRs due to Carbamazepine range from mild maculopapular rash to severe anticonvulsant Hypersensitivity syndrome. An anticonvulsant , Carbamazepine is known to show incidences of cutaneous drug reactions(CDRs), including Steven-johnson syndrome(SJS), Toxic epidermal necrolysis(TEN) and drug induced hypersensitivity (DIHS). AHS is the triad of fever, rash, and internal organ involvement occurring 1-8 weeks after exposure to an anticonvulsant.
Carbamazepine, seizures, pharmacokinetics, pharmacodynamics, Adverse reactions, Cutaneous drug reactions, Steven Johnson , Toxic epidermal necrolysis, Hypersensitivity reactions.