Obesity is often associated with the increase prevalence of chronic diseases such as insulin resistance diabetes mellitus, hypertension, hypercholesterolemia, cerebrovascular accident, heart attack, congestive cardiac diseases, cancer, gallstone formation, gout, etc. The anti-obesity effect of fig fruit in animals fed on cafeteria and atherogenic diet was evaluated. The animals were divided into three major groups viz. Normal diet, cafeteria diet and atherogenic diet. Under these groups, they were further divided into five sub-groups. The first sub-group consists of control animals and they were not treated with any drug. The second sub-group was treated with the standard drug, i.e. ayurslim. The third, fourth and fifth sub-groups were treated with fig fruit at the dose of 100, 150 and 200mg/kg respectively. The treatment period was 40 days. After 40 days, change in body weight, lipid profile and CNS activity were evaluated in all the groups. There was a significant reduction in body weight, locomotor activities, fat pad weights (kidney fat, mesenteric fat and uterine fat), cholesterol, and triglycerides, LDL, VLDL level and increased in HDL level of the animals treated with ayurslim and fig fruit. These results suggest that fig fruit possessed potent anti-obesity activity.