Abstract: T2DM is a primary cause of illness and death globally, as well as a significant economic burden. T2DM is becoming increasingly common, implying that more effective preventive and treatment techniques are required. An in vitro research of medicinal plants was conducted to investigate their potential anti-diabetic and anti-obesity effects. Assays for ferric reducing antioxidant power (FRAP) and DPPH• scavenging capacity were performed on hot water (WE) and ethanol (EE) extracts of sweet gale (Myrica gale L.), roseroot (Rhodiola rosea L.), sheep sorrel (Rumex acetosa L.), stinging nettles (Utrica dioica L.), and dandelions (Taraxacumofficinale L.). Study of 3T3-L1 preadipocytes also indicated that Myrica gale EE (54.8%) and nettles (62.2%) strongly reduced in vitro adipogenesis (p0.05). There is a possibility that the polyphenols in these medicinal plants might be used to manage type 2 diabetes and obesity.