ABSTRACT: Nanocrystals show promise to deliver poorly water-soluble drugs to yield systemic exposure. However, our knowledge is regarding the in vivo fate of nanocrystals is in its infancy, as Nano crystallization is simply viewed as an approach to enhance the dissolution of drug crystals. Nanocrystals also offer the advantage of long-term durability in the body for interacting with biological tissues and cells. Nanocrystals are nanosized drug moieties comprising 100% of the drug with insignificant amounts of stabilizer. Their nanoscale dimensions bestow upon them key attributes such as improved dissolution rate due to increase surface area,increased permeability due to increased adhesion, which contributes to improved bioavailability. Significance of nanocrystal drugs is mentioned in this review. They are used as a physical approach to alter and improve the pharmacokinetic and pharmacodynamic properties of various types of drug molecules. The method of preparations of nanocrystals is down,top down and bottom up, spray drying and so new techniques. Nanocrystallization is a versatile method for salvaging poorly soluble drugs with the added benefit of a carrier-free delivery system. Additionally, it delves into the integration of nanocrystals in the drug development process, exploring their potential to revolutionize formulation strategies and improve therapeutic efficacy. This review provides insights into the evolving landscape of nanocrystals in pharmaceutical applications, emphasizing their transformative impact on drug development and regulatory compliance. This review articles include method of preparation, properties, advantages of nanocrystals and applications of nanocrystals through all routes of administrations.
Dr. Valikala Viswanath, P. Lakshmi Prasanna, D. Swetha, K. Rohitha, S. Haripriya, Trivikram rao
Nano crystals, Nanoparticles, Nanotechnology, Nanotherapeutics, nanoscience