Abstract: – Arround 23 to 41 million people suffering from IBS. There are number of treatment to available treat IBS but some of them side effect of constipation. So we need drug to cure IBS as well as constipation. High dose of drug cause severe side effect in IBS condition. So to avoid this high potency drug required and use of other drug can cause side effect like constipation. Lubiprostone is high potency drug, low dose and give good therapeutic effect and also treat IBS with constipation. To improve patient compliance prepare extended release tablet.

Keyword: IBS, Lubiprostone, Therapeutic effect