Abstract: The present study was undertaken to evaluate the phytochemical and pharmacological activity of the ethanolic extract of Abutilon indicum for its antiepileptic potential using experimental animal models. Preliminary phytochemical screening of the extract revealed the presence of flavonoids, alkaloids, tannins, phenolic compounds, glycosides, and saponins, which are known for their neuroprotective and antioxidant properties. Acute toxicity studies were performed according to Organization for Economic Co-operation and Development guideline 423, and the extract was found to be safe up to 2000 mg/kg body weight. Based on the toxicity results, doses of 200 mg/kg and 400 mg/kg were selected for pharmacological evaluation. Antiepileptic activity was assessed using the Maximal Electroshock Seizure (MES) model in Wistar albino rats. Behavioral and motor coordination studies were carried out using Open Field and Rotarod tests. The extract exhibited significant dose-dependent antiepileptic activity by improving locomotor activity, exploratory behavior, and motor coordination. Biochemical analysis showed a significant increase in GABA and catalase levels along with a reduction in glutamate concentration and lipid peroxidation levels, indicating reduction of neuronal excitability and oxidative stress. The higher dose (400 mg/kg) showed effects comparable to the standard drug Diazepam. The results of the present investigation suggest that the ethanolic extract of Abutilon indicum possesses significant antiepileptic and neuroprotective activity, which may be attributed to its phytoconstituents with antioxidant properties. The study supports the traditional use of the plant and indicates its potential as a natural therapeutic agent for the management of epilepsy.