Abstract: The present study evaluated the antidiabetic and antioxidant potential of the ethanolic extract of Momordica foetida in Streptozotocin (STZ)-induced diabetic Wistar rats. Diabetes was induced by a single intraperitoneal injection of STZ (45–55 mg/kg). After confirmation of hyperglycemia, animals were treated orally for 21 days with the plant extract at doses of 200 and 400 mg/kg. Metformin (5 mg/kg, p.o.) served as the standard drug. Biochemical evaluations included fasting blood glucose, lipid profile (TC, TG, HDL, LDL, VLDL), liver function enzymes (AST, ALT, ALP), kidney function markers (urea, creatinine), and pancreatic antioxidant parameters (SOD, CAT, GSH, MDA). Diabetic control rats showed significant hyperglycemia, dyslipidemia, elevated hepatic and renal markers, and increased oxidative stress with reduced antioxidant enzyme levels. Treatment with the ethanolic extract of Momordica foetida produced a dose-dependent reduction in blood glucose and lipid abnormalities, restored liver and kidney function markers, and significantly improved pancreatic antioxidant status by elevating SOD, CAT, and GSH while decreasing MDA levels. The higher dose (400 mg/kg) showed effects comparable to Metformin. The study concludes that Momordica foetida exhibits significant antidiabetic activity mediated through antihyperglycemic, antihyperlipidemic, hepatoprotective, reno protective, and antioxidant mechanisms, supporting its traditional use and potential for development as a natural antidiabetic agent.