Supercritical Fluid Chromatography (SFC) is an advanced chromatographic technique that uses a supercritical fluid — most commonly carbon dioxide (CO₂) — as the mobile phase to separate components in complex mixtures. SFC bridges the gap between gas chromatography (GC) and high-performance liquid chromatography (HPLC), combining the best characteristics of both techniques: gas-like diffusivity and liquid-like solvating power.