Abstract : Pharmaceutical analysis is a crucial branch of chemistry ensuring drug quality, purity, and safety by identifying,
quantifying, separating, and purifying active ingredients, impurities, and excipients in raw materials and finished products, using
methods from traditional wet chemistry (titration) to advanced instrumental techniques like chromatography (HPLC, TLC) and
spectroscopy (UV-Vis, NMR) to meet regulatory standards and guide drug development. Analytical method development is the
systematic creation, optimization, and documentation of procedures to identify, separate, quantify, and characterize chemical
substances, ensuring the method is accurate, specific, precise, and robust for its intended use, especially crucial in the pharmaceutical
industry for drug quality, purity, and stability. Pacritinib is an oral kinase inhibitor that selectively inhibits JAK2 and FLT3, reducing
abnormal myeloproliferative signalling. Pacritinib is used for the treatment of intermediate- or high-risk myelofibrosis, particularly in
patients with severe thrombocytopenia. Tepotinib is a selective MET tyrosine kinase inhibitor that blocks MET signalling, inhibiting
tumor cell growth and survival. Tepotinib is used for the treatment of metastatic non–small cell lung cancer with MET exon 14
skipping mutations. Vericiguat is a prescription medication primarily used in adults with chronic heart failure to reduce the risk of
death. Sacubitril is primarily used in a fixed-dose combination with the angiotensin receptor blocker valsartan to treat chronic heart
failure. It is not available as a stand-alone medication for the treatment of heart failure