ABSTRACT: The aim of the study was to formulate SR tablets of Valsartan Sodium using different hydrophilic and hydrophobic polymers on in vitro release rate from Valsartan Sodium sustained release tablets. Different types of polymers like HPMC, Carbopol and Ethyl cellulose were used as Sustained release polymers. Formulation 12 showed sustained drug release for 12 hours so it was selected as the best formulation among all the formulations. The Final trial was packed in PVC/PVDC blister packing and kept at 40°C/75%RH±5% for 3 months and 25°C±2°C/60%RH±5% up to 24 months. Formulation found to be robust and stable.