The objective of the present study was to develop self emulsifying drug delivery system of Donazol to improve solubility and dissolution rate of Donazol. Donazol is a BCS class II drug (poor solubility, good permeability) with low bioavailability (less than 5%). In present study Donazol self emulsifying drug delivery system was prepared with triacetin as oil, transcutol as surfactant and propylene glycol as co-surfactant. SMEDDS was characterized for stress study, invitro drug release, globule size, zeta potential, polydispersity index, transmission electron microscopy, exvivo permeation study and pharmacodynamic study. Improvement in antihyperlipidimic potential of SMEDDS as compared to plain drug can be attributed to improvement in solubility and drug dissolution rate of Donazol.