ABSTRACT: Nanogels are an innovative drug delivery system that can play an integral part in pointing out many issues related to old and modern treatment courses such as nonspecific effects and poor stability. Nanogels may be defined as highly cross-linked nano-sized hydrogels ranges from 20-200 nm. They can be administered through various routes, including oral, pulmonary, nasal, parenteral, intra-ocular etc. They have a high degree of drug loading capacity and it shows better permeation capabilities due to a smaller size. They release the drug by pH-responsive, thermosensitive, volume transition, photochemical internalization and Photoisomerization. Nanogel can be synthesized by Photolithographic, modified pullulan, emulsion polymerization, reverse microemulsion polymerization, inverse miniemulsion polymerization and free radical cross- linking polymerization technique. Nanogels can be used for the treatment of cancer, diabetes, inflammation and bone regeneration. This review aims at providing a general introduction on nanogels, recent synthesis methodology and their novel application in different fields.