ABSTRACT: Inotropic support is frequently initiated to improve myocardial contractility and to improve cardiac output. Advances in perioperative care are associated with improvements in the outcomes of CABG. The study was done with an attempt to look into the perioperative use of isotopes in CABG surgeries. To observe various hemodynamic parameters associated with CABG surgery. To assess the isotropic usage in subjects with co morbidity conditions, and to study various complications associated with isotopes and their management in CABG surgery. An Observational descriptive study was conducted on 150 cardiac patients who underwent CABG surgery. Data were collected from patients and evaluated by comparing with the standard guidelines like ACC/AHA and ESC. The data is collected assessed and analyzed by the CHI-SQUARE test and the data obtained was significant. A total of 150 patients are involved in the research which accounted for 46 are females followed by 104 male patients. The majority of the patients involved in the study are in between 40-70 years of age. The use of Noradrenaline (100%) is more when compared with Adrenaline (98.7%) and Dobutamine (24.7%) after surgery. complications such as tachycardias and atrial fibrillation are managed mostly by amiodarone followed by metoprolol and lidocaine. We conclude that Preoperative use of Isotropic therapy was associated with increased hemodynamic stability in most of the subjects and it also causes complications such as atrial fibrillation and tachycardia’s in patients with associated co morbidities. Adrenaline Noradrenalin and Dobutamine, all are suitable for isotropic support during Emergency from cardiopulmonary bypass, produce increases in hemodynamic at constant left atria pressures, Small increases in heart rate.