Abstract:- According to the literature data, cardiac arrhythmias and conduction disturbances are a constant complication of acute coronary artery disease, and in the first day of the disease, they are observed in 90-95% of patients. The priority of reperfusion therapy in the prevention of acute heart failure and improving the prognosis in myocardial infarction is undeniable. Thrombolysis remains an important factor as a cheap and effective method of reperfusion. Identification of factors related to thrombolysis efficacy, including genetic factors, is a unique process.